GHS / LCSS reagent safety

Laboratory reagent safety & hazard reference

Search common reagents by name, CAS, or formula for hazard summaries, handling controls, and incompatibilities. Each record links to its PubChem source and prompts a check of the current product SDS.

Browse reagent records ↓

If exposure or a spill occursStop work and activate the laboratory emergency procedure. For personal exposure, use the eyewash/safety shower and promptly contact onsite response, EHS, or medical services. Do not use a web summary to self-treat poisoning or manage a large spill. Follow Sections 4 and 6 of the actual product SDS.

Known incompatibilities · not exhaustive

High-risk combination alerts

Only combinations supported by authoritative sources and capable of changing waste or handling practice are shown. Absence from this list does not imply compatibility.

TRIzol / guanidine thiocyanate × hypochlorite / acid

Guanidinium lysis waste + bleach or acid

Reactive compounds and toxic gases may form. Never add bleach directly to guanidine-thiocyanate reagent or sample-preparation waste.

Immediate action

Collect separately, label clearly, and follow the product SDS and institutional hazardous-waste procedure.

Thermo Fisher · TRIzol Plus protocol ↗
Sodium hypochlorite × acid / ammonia / ammonium salt

Bleach + acid or ammonia-containing reagent

Incompatible mixing can release hazardous gases; do not use bleach on chemically unidentified waste.

Immediate action

Stop mixing and follow the laboratory gas-release/spill procedure for evacuation and reporting.

PubChem · Sodium hypochlorite LCSS ↗
Sodium azide × acid / copper / lead / silver / mercury

Sodium azide + acid or heavy-metal plumbing

Acids can generate hydrazoic acid and metals can form shock-sensitive azides; azide solutions must not be drain-disposed.

Immediate action

Use a dedicated compatible waste container and have EHS assess historical discharge or suspected deposits.

PubChem · Sodium azide LCSS ↗
Hydrogen peroxide × combustibles / reducing agents / metals

Concentrated peroxide + organic or metal contamination

Concentrated hydrogen peroxide is a strong oxidizer; contamination can accelerate decomposition, heat and gas release, ignite combustibles, or overpressurize a closed vessel.

Immediate action

Never return excess reagent to the stock bottle; isolate a contaminated container and report under the product SDS and institutional oxidizer-spill procedure.

PubChem · Hydrogen peroxide LCSS ↗
Nitric acid × alcohol / acetone / organic waste

Nitric acid + organic solvent or combustible

Nitric acid is both a strong acid and an oxidizer; contact with organics, reducing agents, or unidentified waste can cause violent heat release and toxic gases.

Immediate action

Use a dedicated compatible oxidizing-acid waste container segregated from organic waste; after accidental mixing, stop work, evacuate, and activate EHS response.

PubChem · Nitric acid LCSS ↗

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Disodium phosphate (anhydrous)

Routine priority
CAS 7558-79-4Formula Na₂HPO₄Type Pure substanceSignal word Warning (representative classification)

A common phosphate-buffer component; most sources aggregated by PubChem do not classify it, while some report a serious-eye-irritation classification.

Nucleic acidProteinCell cultureGeneral
Irritant / sensitizer
Expand full safety cardCollapse safety card+

Representative GHS hazard statements

H319Causes serious eye irritation

Handling controls

  • Control dust and wear eye protection during weighing.
  • Confirm anhydrous versus the exact hydrate first; molecular mass and required mass differ by form.

Critical incompatibilities

Strong acids and strong oxidizers; phosphate can precipitate with multivalent metal ions.

Boundary commonly missed

CAS 7558-79-4 is the anhydrous form; mono-, di-, and heptahydrates cannot use the same mass directly, and supplier classifications can differ.

Open PubChem LCSS record · CID 24203 ↗
LCSS → SDS → local controls

How to use this information

  • H-codes and signal words are representative classifications from PubChem LCSS/GHS records; regulatory sources may not be fully identical.
  • Pure substances, solution concentrations, and commercial mixtures can carry different labels. For real work, the container label, current supplier SDS, and institutional risk assessment take precedence.
  • PPE is not a fixed checklist: glove material and change interval depend on chemical, concentration, contact time, and SDS permeation data.
  • This catalog does not provide individualized medical advice or replace occupational limits, waste rules, or laboratory safety training.
Content reviewed: 2026-08-31

For research and laboratory hazard recognition only; not medical advice. In an emergency, contact local emergency services, poison control, and institutional EHS.