GHS / LCSS reagent safety

Laboratory reagent safety & hazard reference

Search common reagents by name, CAS, or formula for hazard summaries, handling controls, and incompatibilities. Each record links to its PubChem source and prompts a check of the current product SDS.

Browse reagent records ↓

If exposure or a spill occursStop work and activate the laboratory emergency procedure. For personal exposure, use the eyewash/safety shower and promptly contact onsite response, EHS, or medical services. Do not use a web summary to self-treat poisoning or manage a large spill. Follow Sections 4 and 6 of the actual product SDS.

Known incompatibilities · not exhaustive

High-risk combination alerts

Only combinations supported by authoritative sources and capable of changing waste or handling practice are shown. Absence from this list does not imply compatibility.

TRIzol / guanidine thiocyanate × hypochlorite / acid

Guanidinium lysis waste + bleach or acid

Reactive compounds and toxic gases may form. Never add bleach directly to guanidine-thiocyanate reagent or sample-preparation waste.

Immediate action

Collect separately, label clearly, and follow the product SDS and institutional hazardous-waste procedure.

Thermo Fisher · TRIzol Plus protocol ↗
Sodium hypochlorite × acid / ammonia / ammonium salt

Bleach + acid or ammonia-containing reagent

Incompatible mixing can release hazardous gases; do not use bleach on chemically unidentified waste.

Immediate action

Stop mixing and follow the laboratory gas-release/spill procedure for evacuation and reporting.

PubChem · Sodium hypochlorite LCSS ↗
Sodium azide × acid / copper / lead / silver / mercury

Sodium azide + acid or heavy-metal plumbing

Acids can generate hydrazoic acid and metals can form shock-sensitive azides; azide solutions must not be drain-disposed.

Immediate action

Use a dedicated compatible waste container and have EHS assess historical discharge or suspected deposits.

PubChem · Sodium azide LCSS ↗
Hydrogen peroxide × combustibles / reducing agents / metals

Concentrated peroxide + organic or metal contamination

Concentrated hydrogen peroxide is a strong oxidizer; contamination can accelerate decomposition, heat and gas release, ignite combustibles, or overpressurize a closed vessel.

Immediate action

Never return excess reagent to the stock bottle; isolate a contaminated container and report under the product SDS and institutional oxidizer-spill procedure.

PubChem · Hydrogen peroxide LCSS ↗
Nitric acid × alcohol / acetone / organic waste

Nitric acid + organic solvent or combustible

Nitric acid is both a strong acid and an oxidizer; contact with organics, reducing agents, or unidentified waste can cause violent heat release and toxic gases.

Immediate action

Use a dedicated compatible oxidizing-acid waste container segregated from organic waste; after accidental mixing, stop work, evacuate, and activate EHS response.

PubChem · Nitric acid LCSS ↗

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Potassium chloride

Routine priority
CAS 7447-40-7Formula KClType Pure substanceSignal word No uniform signal word

A common buffer, electrolyte, and culture-medium component; most classifications aggregated by PubChem do not classify it as GHS hazardous, while dust and concentrated solutions still require routine controls.

Nucleic acidProteinCell cultureGeneral
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Representative GHS hazard statements

This source does not provide one set of H-codes that applies to every form or concentration. Open the source and check the current product SDS.

Handling controls

  • Avoid dust, ingestion, and eye contact, and clean the work surface after weighing.
  • Label stock concentration and intended use to prevent it being mistaken for a ready-to-use isotonic solution.

Critical incompatibilities

Strong oxidizers; mixture compatibility depends on the other components.

Boundary commonly missed

Low intrinsic hazard does not remove the biological effects of concentrated electrolyte or cover additives and biological contaminants.

Open PubChem LCSS record · CID 4873 ↗
LCSS → SDS → local controls

How to use this information

  • H-codes and signal words are representative classifications from PubChem LCSS/GHS records; regulatory sources may not be fully identical.
  • Pure substances, solution concentrations, and commercial mixtures can carry different labels. For real work, the container label, current supplier SDS, and institutional risk assessment take precedence.
  • PPE is not a fixed checklist: glove material and change interval depend on chemical, concentration, contact time, and SDS permeation data.
  • This catalog does not provide individualized medical advice or replace occupational limits, waste rules, or laboratory safety training.
Content reviewed: 2026-08-31

For research and laboratory hazard recognition only; not medical advice. In an emergency, contact local emergency services, poison control, and institutional EHS.